Project code: PN-IV-P7-7.1-PED-2024-1393

Financed by: UEFISCDI - Executive Agency for Higher Education, Research, Development and Innovation Funding

Partners: The "Alexandru Ioan Cuza" University of Iasi, Antibiotice S.A.

Objectives:

1. Selection, structure optimization of synthetic tricyclic 1,3-dithiolium flavonoids and evaluation of their structural stability.

2. To test the antimicrobial properties of 1,3-dithiolium flavonoids. The susceptibility of a wide range of bacteria to 1,3-dithiolium flavonoids will be assessed in relation with reference antibiotics; MIC/MBC/MFC values will be determined for future practical applications.

3. To investigate the cytotoxicity effects of the 1,3-dithiolium flavonoids. The output of this objective will guide us through an opinion about the potential use of these compounds as new antibacterial drugs/disinfectants/antiseptics.

4. Comparative analysis of the results for laboratory validation of the best candidate as antibacterial agent.

5. Project Management / Dissemination / Results implementation.