Grup de cercetare

Acronim: HETNANMED

Adresă pagina web: http://teclu.chem.uaic.ro/hetnanmed/

Echipa:

Coordonatorul grupului de cercetare: 

Prof. univ. dr. Ionel MANGALAGIU

Membri permanenți:

Prof. univ. dr. habil. Gheorghiță ZBANCIOC (http://teclu.chem.uaic.ro/zbancioc)

Prof. univ. dr. Ramona DĂNAC (http://teclu.chem.uaic.ro/danac/)

Prof. univ. dr. Costel MOLDOVEANU (http://teclu.chem.uaic.ro/moldoveanu)

C.S.II dr. Violeta MANGALAGIU

Conf. univ. dr. Vasilichia ANTOCI

Conf. univ. dr. Dorina AMĂRIUCĂI-MANTU

ACS. Dr. Dumitrela DIACONU 

Membri asociați:

Șef lucr. univ. dr. Roxana TUCALIUC (https://www.uaiasi.ro/horticultura/CV_RTucaliuc.php )

C.S.III dr. ing. Cătălina CIOBANU (https://ici.uaic.ro/cs-iii-dr-ing-catalina-ionica-ciobanu/ )

Studenți:

Drd. Roxana CIORTEANU

Drd. Camelia MARANDIȘ

Drd. Marius SAVU

Drd. Ashraf AL-MATARNEH

Drd. Ana-Maria BÎRGOANU

Drd. Andreea DĂNILĂ 

Direcții de cercetare:

Infrastructura:

• Spectrometru de masă de înaltă rezoluție (HRMS) Orbitrap Exploris 120, Fischer Thermo Scientific;
• Spectrometru de masă cuplat cu gaz cromatograf GCMS QP-2010, Shimadzu;
• Spectrometru de emisie cu sferă integratoare Spectrofluorometer FS5, Edinburgh Instruments;
• Incintă pentru lucru în atmosferă inertă Glovebox Labstar 15603, M. Braun;
• Analizator elemental (CHNS/O) FlashSmart^TM Elemental Analyzer, Fischer Thermo Scientific;
• Spectrofotometru FTIR Cary 630 FTIR, Agilent;
• Spectrofotometru UV-VIS UV-1800, Shimadzu;
• Reactoare cu microunde (Monowave 50 și Monowave 300 de la Anton Paar și Star System 2 de la CEM), ultrasunete (Sonics Vibra cell și Bandelin Sonopuls GM3200);
• Liofilizator ALPHA 1-2 LD Plus, Martin Christ.

Cele mai relevante 15 articole realizate în cadrul grupului de cercetare:

1.     Mangalagiu, V., Danac, R., Diaconu, D., Zbancioc, G., Mangalagiu, I.I. Hybrids Diazine: Recent Advancements in Modern Antimicrobial Therapy (2024) Current Medicinal Chemistry, 31 (19), pp. 2687-2705. DOI: 10.2174/0929867330666230418104409

2.     Zbancioc, G., Mangalagiu, I.I., Moldoveanu, C. The Effective Synthesis of New Benzoquinoline Derivatives as Small Molecules with Anticancer Activity (2024) Pharmaceuticals, 17 (1), art. no. 52, . DOI: 10.3390/ph17010052

3.     Oniciuc, L., Amăriucăi-Mantu, D., Diaconu, D., Mangalagiu, V., Danac, R., Antoci, V., Mangalagiu, I.I. Benzoquinoline Derivatives: An Attractive Approach to Newly Small Molecules with Anticancer Activity (2023) International Journal of Molecular Sciences, 24 (9), art. no. 8124, . DOI: 10.3390/ijms24098124

4.     Amariucai-Mantu, D., Mangalagiu, V., Bejan, I., Aricu, A., Mangalagiu, I.I. Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy (2022) Pharmaceutics, 14 (10), art. no. 2026, . DOI: 10.3390/pharmaceutics14102026

5.     Zbancioc, G., Ciobanu, C.-I., Mangalagiu, I.I., Moldoveanu, C. Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach (2022) Molecules, 27 (10), art. no. 3180, . DOI: 10.3390/molecules27103180

6.     Craciun, A.-M., Rotaru, A., Cojocaru, C., Mangalagiu, I.I., Danac, R. New 2,9-disubstituted-1,10-phenanthroline derivatives with anticancer activity by selective targeting of telomeric G-quadruplex DNA (2021) Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 249, art. no. 119318, . DOI: 10.1016/j.saa.2020.119318

7.     Antoci, V., Oniciuc, L., Amariucai-Mantu, D., Moldoveanu, C., Mangalagiu, V., Amarandei, A.M., Lungu, C.N., Dunca, S., Mangalagiu, I.I., Zbancioc, G. Benzoquinoline derivatives: A straightforward and efficient route to antibacterial and antifungal agents (2021) Pharmaceuticals, 14 (4), art. no. 335, . DOI: 10.3390/ph14040335

8.     Popovici, L., Amarandi, R.-M., Mangalagiu, I.I., Mangalagiu, V., Danac, R. Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives (2019) Journal of Enzyme Inhibition and Medicinal Chemistry, 34 (1), pp. 230-243. DOI: 10.1080/14756366.2018.1550085

9.     Mantu, D., Antoci, V., Moldoveanu, C., Zbancioc, G., Mangalagiu, I.I. Hybrid imidazole (benzimidazole)/pyridine (quinoline) derivatives and evaluation of their anticancer and antimycobacterial activity (2016) Journal of Enzyme Inhibition and Medicinal Chemistry, 31, pp. 96-103. DOI: 10.1080/14756366.2016.1190711

10.  Moldoveanu, C., Zbancioc, G., Mantu, D., Maftei, D., Mangalagiu, I. The cycloaddition of the benzimidazolium ylides with alkynes: New mechanistic insights (2016) PLoS ONE, 11 (5), art. no. e0156129, . DOI: 10.1371/journal.pone.0156129

11.  Zbancioc, G., Mangalagiu, I.I., Moldoveanu, C. Ultrasound assisted synthesis of imidazolium salts: An efficient way to ionic liquids (2015) Ultrasonics Sonochemistry, 23, pp. 376-384. DOI: 10.1016/j.ultsonch.2014.10.028

12.  Danac, R., Mangalagiu, I.I. Antimycobacterial activity of nitrogen heterocycles derivatives: Bipyridine derivatives. Part III [13,14] (2014) European Journal of Medicinal Chemistry, 74, pp. 664-670. DOI: 10.1016/j.ejmech.2013.09.061

13.  Zbancioc, G., Zbancioc, A.M., Mangalagiu, I.I. Ultrasound and microwave assisted synthesis of dihydroxyacetophenone derivatives with or without 1,2-diazine skeleton (2014) Ultrasonics Sonochemistry, 21 (2), pp. 802-811. DOI: 10.1016/j.ultsonch.2013.09.012

14.  Tucaliuc, R.-A., Cotea, V.V., Niculaua, M., Tuchilus, C., Mantu, D., Mangalagiu, I.I. New pyridazine-fluorine derivatives: Synthesis, chemistry and biological activity. Part II (2013) European Journal of Medicinal Chemistry, 67, pp. 367-372. DOI: 10.1016/j.ejmech.2013.04.069

15.  Bejan, V., Mantu, D., Mangalagiu, I.I. Ultrasound and microwave assisted synthesis of isoindolo-1,2-diazine: A comparative study (2012) Ultrasonics Sonochemistry, 19 (5), pp. 999-1002. DOI: 10.1016/j.ultsonch.2012.02.012

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